Automatic Urticaria Activity Score

Automatic Urticaria Activity Score (AUAS): A Novel Technology for Urticaria Severity Assessment Based on Automatic High-Precision Hive Counting 

Table of Contents

    Keywords: Chronic urticaria, UAS, UAS7, Artificial Intelligence, Automatic severity assessment, CADx system

    Introduction

    We introduce AUAS, an automatic equivalent of UAS that deploys a deep learning lesion-detecting algorithm, called Legit.Health-UAS-HiveNet. Our results show that our algorithm assesses the severity of Chronic Urticaria cases with a performance comparable to that of expert physicians.

    Furthermore, the algorithm can be implemented into CADx systems to support doctors in their clinical practice and act as a new endpoint in clinical trials.

    Do you want to see the Automatic UAS7 artificial intelligence in action?

    • auto_storiesRead the paperAutomatic Urticaria Activity Score (AUAS): A Novel Technology For Urticaria Severity Assessment Based On Automatic High-Precision Hive Counting.

    The real impact of the Legit.Health-UAS-HiveNet in clinical practice resides on the power to support physicians during not only the diagnostic process but also in the monitoring of patients with chronic types of urticaria, by helping them prescribe treatments and increase the adequacy of treatments.

    Automatic Urticaria Activity Score (AUAS): A Novel Technology For Urticaria Severity Assessment Based On Automatic High-Precision Hive Counting

    Regarding clinical trials, the AUAS has the potential of becoming a new clinical endpoint that could increase both the quality and the quantity of data available to researchers.

    Automatic Urticaria Activity Score (AUAS): A Novel Technology For Urticaria Severity Assessment Based On Automatic High-Precision Hive Counting

    Authors of the publication

    Taig Mac Carthy

    Taig Mac Carthy

    Department of Clinical Endpoint Innovation

    Legit.Health
    Dr. Rubén García

    Dr. Rubén García

    Dermatology Unit

    FJD Teaching Hospital
    Dr. Ana María González

    Dr. Ana María González

    Dermatology Unit

    Zamora Hospital
    Dr. Alejandro Vilas

    Dr. Alejandro Vilas

    Dermatology Unit

    Ferrol Teaching Hospital
    Dr. Laura Vergara

    Dr. Laura Vergara

    Dermatology Unit

    Toledo Teaching Hospital,
    Dr. Fernando Alfageme

    Dr. Fernando Alfageme

    Dermatology Unit

    Puerta de Hierro Hospital

    What is urticaria severity scoring?

    Urticaria is a very common disease characterized by erythematous, edematous, itchy, and transient plaques that involve the skin and mucous membranes. It can be classified into subtypes such as acute spontaneous urticaria, chronic spontaneous urticaria, chronic inducible urticaria, and episodic chronic urticaria.

    Diagnosis of chronic urticaria is usually performed through clinical observation. In other words: the assessment of the disease’s severity is performed through manual scoring systems that are filled in subjectively.

    The most commonly used scoring system is the Urticaria Activity Score (UAS), which can also be used for 7 consecutive days, in which case it is referred to as UAS7.

    The problem with visual scoring

    The most indisputable limitation of manual scoring systems is the inherent difficulty of human beings to quantify parameters in an objective, stable and precise way.

    Humans have a limited ability to count hives, quantify the surface area of a lesion or quantify the redness of an area. This human limitation in parameter estimation is also reflected in the effort and time required to complete the urticaria activity questionnaires, which end up being a very unrewarding task for patients and may result in poor adherence.

    On the other hand, scoring systems classify disease severity using a limited range of scores, with three or four categories, such as: none, mild, moderate and severe in the case of the UAS. Indeed, questionnaires have a very high minimum detectable change, as they are discrete ranges rather than continuous scales.

    And finally, these questionnaires are susceptible to bias. This is especially true in cases where the patient knows that the treatment they receive will be determined by the information they provide. And due to the asynchronous nature of the reported measure, the clinical team lacks the means to ensure that the values reported by the patient are chronologically accurate or simply truthful, which precludes external verification.

    The goal of the Automatic UAS

    In this work, we propose the Automatic Urticaria Activity Score (AUAS), an automatic version of the objective part of the UAS that applies convolutional neural networks to count hives automatically with high precision.

    The goal is to assist clinicians in filling scoring systems such as the UAS in a more objective way and quicker, which could improve health outcomes and provide high-quality endpoints to measure the effectiveness of the treatments for urticaria.

    Automatic Urticaria Activity Score
    Explanation of how the artificial intelligence identifies hives in urticaria images.

    The solution

    We trained trained a hive-counting neural network called Legit.Health-UAS-HiveNet.

    With the goal of making the artificial intelligence accessible to the healthcare professional, we developed a fully integrated CADx system, a web application that integrates Legit.Health-UAS-HiveNet algorithm and calculates the patient-based UAS by looking at images taken with smartphone cameras.

    The CADx system works in three stages: image and itchiness input, processing of the images, and the creation of a report with the severity assessment.

    Caption of a full report from the CADx system. The chart at the top right shows the evolution of the urticaria, by plotting the AUAS scores across time.
    Caption of a full report from the CADx system. The chart at the top right shows the evolution of the urticaria, by plotting the AUAS scores across time.

    The report can also combine the scores of multiple images uploaded in the same day to provide the global AUAS score.

    In other words: if the user uploads pictures of several body parts, the report of the CADx system shows both the local and the global AUAS scores. The global AUAS is calculated by summing the results of all the images processed by the CADx system

    Automatic Urticaria Activity Score
    Automatic Urticaria Activity Score

    Do you want to see the Automatic UAS artificial intelligence in action?

    Conclusion

    In this work, we have presented the AUAS, the first artificial intelligence that automatically fills in the UAS scoring system by looking at smartphone images. The main advances in this algorithm are reducing the time spent by patients in filling in the manual severity scoring system and standardizing urticaria assessment with reduced inter-observer variability and higher reliability.

    We were able to overcome clinical assessment variability by developing a merging algorithm that fuses all experts’ annotations to create a consensus.

    The AUAS as a scoring system presents improved clinimetric properties, but it also carries the advantage of providing a picture of the lesion along with the severity score, which allows researchers greater oversight of studies. In conclusion, we believe that the AUAS and Legit.Health-UAS-HiveNet has the potential of improving health outcomes, reducing costs, and increasing the practice of evidence-based medicine in health organizations.

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    Automatic Urticaria Activity Score (AUAS): A Novel Technology for Urticaria Severity Assessment Based on Automatic High-Precision Hive Counting 

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