A Closer Look at Dermatology Imaging: Legit.Health and Quantificare

📣 Important update​

As of September 2025, Legit.Health and Quantificare have partnered to combine their strengths in AI and imaging hardware. This collaboration aims to provide a comprehensive solution for dermatology clinical trials, leveraging Legit.Health's AI capabilities alongside Quantificare's 2D and 3D imaging technology and expertise in medical research and drug development. For more details, please refer to our announcement blog post.

Introduction​

This document has been crafted to help you understand the fundamental differences between Quantificare and Legit.Health, specially for clinical trials for diseases such as psoriasis, alopecia or hidradenitis suppurativa, among others. While both companies aim to improve the efficiency and reliability of clinical trial imaging, they do so through very different and complementary approaches:

• Quantificare focuses on specialised 2D and 3D imaging hardware and high-quality data capture.
• Legit.Health provides an AI-driven software that automates the extraction of clinical endpoints from images.

The goal of this comparison is to help you understand how each platform addresses key areas that matter in clinical trials. Furthermore, it aims to demonstrate why the partnership between Legit.Health and Quantificare can offer the best complementary solutions for a global dermatology clinical trial.

How the Partnership Works​

The Legit.Health and Quantificare partnership creates a seamless workflow that combines the best of both technologies:

Integrated Workflow​

1. Image Capture: Clinical sites use Quantificare's specialized 2D/3D cameras for high-quality, standardized imaging when volumetric data is needed, or standard devices with Legit.Health's DIQA when 2D imaging suffices.
2. AI Analysis: Legit.Health's AI automatically processes all images (whether from Quantificare hardware or standard cameras) to:
   • Detect and count lesions
   • Measure clinical signs
   • Calculate severity scores
3. Combined Reporting: Both platforms integrate to provide:
   • 3D volumetric measurements from Quantificare
   • AI-powered clinical assessments from Legit.Health
   • Unified dashboard for trial managers

Product overview​

In this section, we'll explore the essence of each company's offerings. Understanding these product portfolios will help demonstrate why the combination of both Legit.Health and Quantificare offers the most powerful solution for sponsors running dermatology clinical trials.

Quantificare​

Quantificare offers imaging solutions that revolve around their proprietary 2D and 3D photography systems. These systems, such as the 2D DermaViz® Series and the 3D LifeViz® Series, capture volumetric data, which can be highly valuable in certain dermatological or plastic surgery contexts where depth measurements are essential.

3D Photography system​

Quantificare's most distinctive solution is a specialised 3D camera system designed to deliver consistent, high-resolution images across multiple angles. This stereoscopic system allows to consistently document any part of the body with unmatched accuracy and precision. It is often accompanied by a range of software tools that enable clinicians or researchers to visualise and measure lesion volumes, surface irregularities, and other three-dimensional aspects.

Clinical trials photography (2D)​

Although their flagship offering revolves around 3D imaging, Quantificare also provides 2D imaging solutions, exemplified by the 2D DermaViz® Series. The 2D DermaViz® Series is a fully handheld photography device equipped with fixed optics and a built-in ranging light system, ensuring high-quality, reproducible images.

Legit.Health​

By comparison, Legit.Health is predominantly an artificial intelligence developer to automate the detection and measurement of clinical signs. This means:

• Pre-trained algorithms that cover a wide range of clinical signs and scoring systems, drastically reducing manual workloads and increasing reliability of outcome measures.
• A built-in Digital Image Quality Assessment (DIQA) system that ensures images meet the required standard for accurate analysis.

Clinical signs measured by Legit.Health​

Legit.Health can automatically detect, measure, or quantify the following clinical signs:

• Inflammatory Signs:
  • Erythema
  • Oedema
  • Swelling
  • Exudation
  • Oozing
• Tissue Characteristics:
  • Desquamation
  • Induration
  • Crusting
  • Dryness
  • Excoriation
  • Lichenification
  • Depth
  • Edges
  • Undermining
  • Granulation tissue
  • Epithelialization
  • Type of necrotic tissue
  • Amount of necrotic tissue
• Lesion Types & Counts:
  • Nodule count
  • Papule count
  • Pustule count
  • Cyst count
  • Comedone count
  • Abscess count
  • Draining tunnel count
  • General lesion count
• Other Measurements:
  • Hair density
  • Pustulation
  • Type of exudate
  • Peripheral tissue edema
  • Peripheral tissue induration

Scoring systems covered by Legit.Health​

Legit.Health also supports a variety of dermatological scoring systems—key for clinical trials that require standardised metrics:

• Psoriasis: PASI
• Hidradenitis Supurativa: IHS4, Hurley, HiSCR,
• Atopic Dermatitis: SCORAD, EASI,
• Alopecia: SALT, Ludwig
• Urticaria: UAS7
• Wounds: AWOSI
• Generalized Pustular Psoriasis: GPPGA
• Vitiligo: VASI
• Acne: GAGS, ALADIN

and more

By automating these measurements, Legit.Health not only reduces the operational burden on study coordinators but also minimises human error, ensuring consistent and reproducible results across all trial sites.

Comparison​

In essence, Quantificare aims to perfect the capture of volumetric data, whereas Legit.Health focuses on extracting clinical endpoints rapidly and accurately across multiple sites, with minimal technological overhead.

Capability Comparison​

The following table summarises the key capabilities of each platform, highlighting the strengths of the combined solution:

This comparison illustrates how the two platforms complement each other. While Quantificare provides unparalleled 3D imaging capabilities, Legit.Health excels in automating the extraction of clinical endpoints, making it easier to conduct large-scale dermatology trials with consistent and reliable data.

Use case: Hidradenitis Suppurativa​

Hidradenitis Suppurativa (HS) is characterised by painful, inflamed lesions often hidden in folds of the skin. Achieving reliable, reproducible measures of lesion severity across multiple sites can be challenging.

Legit.Health overcomes these challenges by:

1. Automatically detecting lesions such as nodules, draining tunnels and abscesses using AI, eliminating the need for manual counts.
2. Measuring severity in terms of the relevant scoring system, such as IHS4 or Hurley.
3. Ensuring image quality through automated checks and balances.
4. Enabling immediate feedback of disease progression to reduce data turnaround time and minimise human error.

On the other hand, Quantificare offers 3D volumetric data capture, which is often necessary for diseases such as HS. Quantificare's hardware-based approach ensures that the depth of lesions can be accurately assessed, which is crucial for understanding the severity and progression of HS.

Thanks to the partnership, sponsors can employ Quantificare's hardware for depth capture and use Legit.Health's AI software for reliable endpoint extraction.

Conclusion​

Choosing the right technology partner for a clinical trial entails weighing data accuracy, operational complexity, regulatory compliance, and cost-effectiveness. While Quantificare excels at 3D imaging for conditions requiring volumetric assessments, Legit.Health streamlines and automates the majority of dermatological endpoints, particularly those pivotal in Hidradenitis Suppurativa, Alopecia, Acne or Psoriasis, among others. Its user-friendly software approach:

• Reduces logistical hurdles for trial sites,
• Ensures rapid deployment at scale,
• Guarantees regulatory compliance, and
• Eliminates much of the manual labour traditionally involved in clinical data gathering.

Ultimately, the combination of both Quantificare and Legit.Health emerges as the more efficient, timely, and cost-effective solution for trials targeting dermatological conditions, offering fast and accurate clinical endpoint extraction with minimal training or maintenance required.